15 Hearty Fall Main Dish Casserole Recipes You’ll Love

Fall is the perfect season for warm, comforting meals that bring family and friends together.

Casseroles are versatile, hearty, and ideal for incorporating seasonal ingredients like squash, root vegetables, and savory meats.

These 15 fall main dish casserole recipes showcase the best ways to enjoy cozy, flavorful dinners during the autumn months.

From cheesy baked pasta dishes to savory meat-and-vegetable bakes, there is a casserole for every palate.

Preparing casseroles in advance makes weeknight dinners easier and perfect for entertaining.

Using seasonal produce and hearty proteins creates filling, satisfying meals for cooler evenings.

Exploring these recipes will inspire creativity and bring warmth to your fall dinner table.

Whether you enjoy traditional favorites or modern twists, these casseroles are sure to delight.

15 Hearty Fall Main Dish Casserole Recipes You’ll Love

Casseroles are the ultimate comfort food for fall, combining heartiness, flavor, and convenience.

These 15 fall main dish casserole recipes range from cheesy pasta bakes and layered vegetable dishes to protein-packed meat casseroles.

They are perfect for family dinners, holiday gatherings, or casual weeknight meals.

Using seasonal ingredients elevates each dish with fresh, autumn flavors.

With these recipes, you can enjoy warm, satisfying, and easy-to-prepare meals all season long.

Autumn Harvest Chicken and Rice Casserole

This autumn harvest chicken and rice casserole is hearty, flavorful, and perfect for fall evenings.

Tender chicken pieces are combined with rice, carrots, celery, and seasonal spices, creating a comforting one-dish meal.

The creamy sauce binds the ingredients together while baking to golden perfection.

It’s ideal for family dinners or meal prep for busy autumn weeks.

Ingredients:

• 2 cups cooked chicken, diced
• 1 cup uncooked white rice
• 1 cup carrots, diced
• 1 cup celery, diced
• 1 small onion, diced
• 2 cloves garlic, minced
• 1 can (10 oz) cream of mushroom soup
• 1 cup chicken broth
• 1 teaspoon thyme
• 1/2 teaspoon paprika
• Salt and pepper to taste
• 1 cup shredded cheddar cheese

Instructions:

• Preheat oven to 375°F (190°C).
• In a large mixing bowl, combine chicken, rice, carrots, celery, onion, garlic, thyme, paprika, salt, and pepper.
• Stir in cream of mushroom soup and chicken broth until evenly mixed.
• Transfer mixture to a greased 9×13-inch baking dish.
• Cover with foil and bake for 35 minutes.
• Remove foil, sprinkle cheddar cheese on top, and bake another 10 minutes until golden and bubbly.

This autumn harvest chicken and rice casserole is savory, creamy, and satisfying.

It’s perfect for cozy fall dinners with family.

The tender chicken and seasonal vegetables create a comforting, hearty meal.

Butternut Squash and Sausage Casserole

This butternut squash and sausage casserole is rich, savory, and full of warm fall flavors.

Roasted butternut squash is paired with Italian sausage, onions, and a creamy herb sauce for a one-dish meal.

The combination of sweet squash and savory sausage is both comforting and festive.

It’s ideal for family gatherings or a cozy weekend dinner.

Ingredients:

• 3 cups butternut squash, peeled and cubed
• 1 lb Italian sausage, casing removed
• 1 onion, diced
• 2 cloves garlic, minced
• 1/2 cup heavy cream
• 1/2 teaspoon thyme
• 1/2 teaspoon sage
• Salt and pepper to taste
• 1/2 cup shredded mozzarella cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Toss butternut squash with olive oil, salt, and pepper, and roast 20 minutes until tender.
• In a skillet, cook sausage until browned; add onions and garlic, cooking until fragrant.
• Combine roasted squash, sausage mixture, cream, thyme, and sage in a baking dish.
• Top with mozzarella cheese and bake 20–25 minutes until bubbly and golden.

This butternut squash and sausage casserole is hearty, flavorful, and aromatic.

It’s perfect for autumn dinners or family gatherings.

The sweet squash and savory sausage make a balanced, comforting dish.

Fall Vegetable and Cheddar Casserole

This fall vegetable and cheddar casserole is colorful, cheesy, and perfect for seasonal meals.

A mix of roasted vegetables like carrots, broccoli, and cauliflower is bound together with a creamy cheese sauce.

The dish is baked until golden, creating a savory, comforting meal for cooler evenings.

It’s ideal as a vegetarian main dish or a side for family dinners.

Ingredients:

• 2 cups broccoli florets
• 2 cups cauliflower florets
• 1 cup carrots, sliced
• 1 small onion, diced
• 2 cloves garlic, minced
• 2 tablespoons butter
• 2 tablespoons flour
• 1 1/2 cups milk
• 1 teaspoon mustard
• Salt and pepper to taste
• 1 1/2 cups shredded cheddar cheese

Instructions:

• Preheat oven to 375°F (190°C).
• Steam broccoli, cauliflower, and carrots until slightly tender.
• In a saucepan, melt butter, stir in flour to form a roux, and gradually whisk in milk until thickened.
• Add mustard, salt, and pepper; stir in half the cheddar cheese until melted.
• Combine cheese sauce with vegetables and transfer to a greased baking dish.
• Sprinkle remaining cheddar on top and bake 20–25 minutes until golden and bubbly.

This fall vegetable and cheddar casserole is creamy, cheesy, and satisfying.

It’s perfect for a vegetarian main or a comforting side.

The roasted vegetables and rich cheese sauce create a hearty autumn dish.

Sweet Potato and Ground Beef Casserole

This sweet potato and ground beef casserole is hearty, savory, and perfect for autumn dinners.

Layered sweet potatoes, seasoned ground beef, onions, and spices bake together for a rich, comforting one-dish meal.

The natural sweetness of the potatoes complements the savory, spiced beef perfectly.

It’s ideal for weeknight dinners or meal prep during fall.

Ingredients:

• 1 lb ground beef
• 3 cups sweet potatoes, peeled and sliced
• 1 onion, diced
• 2 cloves garlic, minced
• 1 teaspoon paprika
• 1/2 teaspoon thyme
• Salt and pepper to taste
• 1/2 cup shredded cheddar cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• In a skillet, heat olive oil and sauté onions and garlic until fragrant.
• Add ground beef, paprika, thyme, salt, and pepper; cook until browned.
• Layer half the sweet potatoes in a greased baking dish, then half the beef mixture.
• Repeat layers and top with shredded cheddar cheese.
• Cover with foil and bake 35–40 minutes until potatoes are tender; remove foil and bake 10 minutes to brown cheese.

This sweet potato and ground beef casserole is savory, hearty, and satisfying.

It’s perfect for family dinners or cozy fall evenings.

The sweet and savory layers make each bite flavorful and comforting.

Harvest Chicken and Quinoa Casserole

This harvest chicken and quinoa casserole is nutritious, hearty, and perfect for autumn meals.

Chicken, quinoa, roasted vegetables, and a creamy herb sauce combine to create a wholesome, flavorful dish.

The combination of grains, protein, and fall vegetables makes it both satisfying and nourishing.

It’s ideal for weeknight dinners, meal prep, or a cozy weekend meal.

Ingredients:

• 2 cups cooked chicken, diced
• 1 cup quinoa, cooked
• 1 cup butternut squash, cubed
• 1 cup zucchini, diced
• 1 small onion, diced
• 2 cloves garlic, minced
• 1/2 cup heavy cream
• 1 teaspoon thyme
• Salt and pepper to taste
• 1/2 cup shredded mozzarella cheese

Instructions:

• Preheat oven to 375°F (190°C).
• Roast butternut squash and zucchini with olive oil, salt, and pepper until tender.
• In a large bowl, combine chicken, cooked quinoa, roasted vegetables, cream, thyme, salt, and pepper.
• Transfer mixture to a greased baking dish.
• Top with shredded mozzarella and bake 20–25 minutes until bubbly and golden.

This harvest chicken and quinoa casserole is hearty, nutritious, and flavorful.

It’s perfect for fall dinners or meal prep for the week.

The roasted vegetables and creamy sauce create a comforting autumn meal

Cheesy Autumn Broccoli and Chicken Casserole

This cheesy autumn broccoli and chicken casserole is creamy, savory, and perfect for fall dinners.

Tender chicken and roasted broccoli are coated in a rich cheese sauce and baked until golden.

The dish is hearty, flavorful, and ideal for family meals or weeknight dinners.

A sprinkle of crispy breadcrumbs adds a satisfying texture on top.

Ingredients:

• 2 cups cooked chicken, diced
• 3 cups broccoli florets
• 1 small onion, diced
• 2 cloves garlic, minced
• 2 tablespoons butter
• 2 tablespoons flour
• 1 1/2 cups milk
• 1 teaspoon mustard
• Salt and pepper to taste
• 1 1/2 cups shredded cheddar cheese
• 1/2 cup breadcrumbs

Instructions:

• Preheat oven to 375°F (190°C).
• Steam broccoli until slightly tender.
• In a saucepan, melt butter, whisk in flour, and gradually add milk to create a creamy sauce.
• Stir in mustard, salt, pepper, and half the cheddar cheese until melted.
• Combine sauce with chicken and broccoli, then transfer to a greased baking dish.
• Sprinkle remaining cheddar and breadcrumbs on top and bake 20–25 minutes until golden and bubbly.

This cheesy autumn broccoli and chicken casserole is creamy, hearty, and satisfying.

It’s perfect for cozy fall dinners or family meals.

The combination of tender chicken, broccoli, and cheese makes it irresistible.

Harvest Beef and Potato Casserole

This harvest beef and potato casserole is rich, savory, and perfect for autumn evenings.

Ground beef is layered with sliced potatoes, onions, and a creamy sauce, then baked to golden perfection.

The dish is hearty, flavorful, and ideal for family dinners or casual gatherings.

A touch of thyme adds warmth and depth to the flavors.

Ingredients:

• 1 lb ground beef
• 3 cups potatoes, thinly sliced
• 1 onion, diced
• 2 cloves garlic, minced
• 1 cup milk
• 2 tablespoons flour
• 1 teaspoon thyme
• Salt and pepper to taste
• 1/2 cup shredded cheddar cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté onions and garlic in olive oil until fragrant; add ground beef and cook until browned.
• In a saucepan, whisk flour into milk and cook until thickened.
• Layer half the potatoes in a greased baking dish, top with half the beef mixture, then pour half the sauce.
• Repeat layers and top with shredded cheddar cheese.
• Cover with foil and bake 35–40 minutes until potatoes are tender; uncover and bake 10 minutes more to brown cheese.

This harvest beef and potato casserole is hearty, savory, and flavorful.

It’s perfect for fall dinners or weekend family meals.

The tender potatoes and seasoned beef create a comforting autumn dish.

Autumn Turkey and Cranberry Casserole

This autumn turkey and cranberry casserole is savory, slightly sweet, and perfect for fall holidays.

Leftover turkey is combined with wild rice, vegetables, and cranberries in a creamy sauce.

It’s baked until bubbly, creating a comforting and festive meal.

The tart cranberries balance the rich, savory flavors of turkey and vegetables.

Ingredients:

• 2 cups cooked turkey, diced
• 1 cup wild rice, cooked
• 1/2 cup cranberries, dried
• 1 cup carrots, diced
• 1 onion, diced
• 2 cloves garlic, minced
• 1 cup cream of chicken soup
• 1/2 cup milk
• Salt and pepper to taste
• 1/2 cup shredded cheddar cheese

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté onions, garlic, and carrots until tender.
• In a large bowl, combine turkey, cooked rice, sautéed vegetables, cranberries, soup, milk, salt, and pepper.
• Transfer mixture to a greased baking dish and top with shredded cheddar cheese.
• Bake 25–30 minutes until cheese is melted and bubbly.

This autumn turkey and cranberry casserole is flavorful, savory, and lightly sweet.

It’s perfect for fall dinners or holiday gatherings.

The combination of turkey, cranberries, and vegetables makes it a festive, comforting dish.

Creamy Mushroom and Chicken Casserole

This creamy mushroom and chicken casserole is rich, savory, and perfect for cozy autumn nights.

Tender chicken pieces are combined with sautéed mushrooms, onions, and a creamy sauce, then baked to golden perfection.

It’s hearty and comforting, ideal for family dinners or weekend meals.

A sprinkle of fresh herbs adds an aromatic touch.

Ingredients:

• 2 cups cooked chicken, diced
• 2 cups mushrooms, sliced
• 1 onion, diced
• 2 cloves garlic, minced
• 1/2 cup heavy cream
• 1 tablespoon flour
• 1 teaspoon thyme
• Salt and pepper to taste
• 1/2 cup shredded mozzarella cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté mushrooms, onions, and garlic in olive oil until tender.
• Stir in flour, then gradually add cream, thyme, salt, and pepper to create a thick sauce.
• Combine sauce with chicken and transfer to a greased baking dish.
• Sprinkle mozzarella cheese on top and bake 20–25 minutes until bubbly and golden.

This creamy mushroom and chicken casserole is savory, comforting, and satisfying.

It’s perfect for fall dinners or family meals.

The tender chicken and rich mushroom sauce make it a hearty autumn dish.

Sweet Potato, Black Bean, and Beef Casserole

This sweet potato, black bean, and beef casserole is hearty, flavorful, and perfect for fall dinners.

Ground beef, sweet potatoes, and black beans are layered with spices and baked until golden.

It’s filling, nutritious, and ideal for weeknight meals or family gatherings.

The combination of savory beef and naturally sweet potatoes creates a balanced dish.

Ingredients:

• 1 lb ground beef
• 2 cups sweet potatoes, peeled and diced
• 1 can black beans, drained and rinsed
• 1 onion, diced
• 2 cloves garlic, minced
• 1 teaspoon cumin
• 1/2 teaspoon paprika
• Salt and pepper to taste
• 1/2 cup shredded cheddar cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté onions and garlic in olive oil until tender; add ground beef and cook until browned.
• Stir in cumin, paprika, salt, and pepper.
• Layer sweet potatoes, beef mixture, and black beans in a greased baking dish.
• Top with shredded cheddar cheese and bake 30–35 minutes until sweet potatoes are tender and cheese is golden.

This sweet potato, black bean, and beef casserole is hearty, savory, and satisfying.

It’s perfect for fall dinners or casual family meals.

The combination of sweet potatoes, beans, and seasoned beef makes a comforting autumn dish

Autumn Shepherd’s Pie Casserole

This autumn shepherd’s pie casserole is hearty, comforting, and perfect for chilly evenings.

Ground beef and vegetables are simmered in a savory gravy and topped with creamy mashed sweet potatoes.

The golden topping bakes to perfection, creating a warm, flavorful dish that’s ideal for family dinners.

It’s a classic comfort food with a seasonal fall twist.

Ingredients:

• 1 lb ground beef
• 1 cup carrots, diced
• 1 cup peas
• 1 small onion, diced
• 2 cloves garlic, minced
• 2 tablespoons tomato paste
• 1 cup beef broth
• 3 cups mashed sweet potatoes
• Salt and pepper to taste
• 1 teaspoon thyme
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté onions, garlic, carrots, and ground beef in olive oil until browned.
• Stir in tomato paste, beef broth, thyme, salt, and pepper; simmer 5–10 minutes.
• Transfer mixture to a greased baking dish and spread mashed sweet potatoes on top.
• Bake 25–30 minutes until topping is golden and filling is bubbling.

This autumn shepherd’s pie casserole is savory, hearty, and comforting.

It’s perfect for fall family dinners or cozy weekend meals.

The sweet potato topping adds a seasonal twist to a classic favorite.

Harvest Chicken and Vegetable Gratin

This harvest chicken and vegetable gratin is creamy, cheesy, and full of fall flavors.

Tender chicken, roasted root vegetables, and a rich cheese sauce bake together to create a satisfying dish.

It’s perfect for family dinners, entertaining guests, or cozy fall nights.

A crisp breadcrumb topping adds texture and golden color.

Ingredients:

• 2 cups cooked chicken, diced
• 2 cups butternut squash, cubed
• 1 cup carrots, sliced
• 1 small onion, diced
• 2 cloves garlic, minced
• 1 cup heavy cream
• 1 teaspoon thyme
• Salt and pepper to taste
• 1 1/2 cups shredded Gruyère or cheddar cheese
• 1/2 cup breadcrumbs
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Roast butternut squash and carrots with olive oil, salt, and pepper until tender.
• In a saucepan, combine cream, garlic, thyme, salt, and pepper; heat until slightly thickened.
• Mix roasted vegetables, chicken, and cream sauce in a greased baking dish.
• Sprinkle cheese and breadcrumbs on top and bake 20–25 minutes until golden and bubbling.

This harvest chicken and vegetable gratin is creamy, cheesy, and comforting.

It’s perfect for cozy fall dinners or holiday meals.

The roasted vegetables and rich sauce make it a hearty, satisfying dish.

Autumn Turkey, Spinach, and Rice Casserole

This autumn turkey, spinach, and rice casserole is healthy, hearty, and full of seasonal flavors.

Cooked turkey, spinach, and rice are combined with a creamy sauce and baked until golden and bubbly.

It’s ideal for family dinners or a make-ahead weeknight meal.

The fresh spinach and herbs add brightness to the rich, savory casserole.

Ingredients:

• 2 cups cooked turkey, diced
• 1 cup cooked rice
• 2 cups fresh spinach, chopped
• 1 small onion, diced
• 2 cloves garlic, minced
• 1 cup cream of mushroom soup
• 1/2 cup milk
• Salt and pepper to taste
• 1/2 teaspoon thyme
• 1/2 cup shredded mozzarella cheese

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté onions and garlic until fragrant, then stir in spinach until wilted.
• In a large bowl, combine turkey, rice, sautéed vegetables, cream of mushroom soup, milk, thyme, salt, and pepper.
• Transfer mixture to a greased baking dish and top with shredded mozzarella.
• Bake 25–30 minutes until bubbly and golden on top.

This autumn turkey, spinach, and rice casserole is nutritious, hearty, and comforting.

It’s perfect for fall weeknight dinners or family meals.

The combination of turkey, rice, and fresh spinach makes a balanced and satisfying dish.

Sweet Potato, Chicken, and Black Bean Casserole

This sweet potato, chicken, and black bean casserole is hearty, flavorful, and perfect for fall evenings.

Tender chicken, roasted sweet potatoes, and black beans are layered with spices and cheese for a one-dish meal.

It’s ideal for weeknight dinners or casual family gatherings.

The combination of sweet, savory, and slightly spicy flavors creates a balanced autumn dish.

Ingredients:

• 2 cups cooked chicken, diced
• 2 cups sweet potatoes, cubed
• 1 can black beans, drained and rinsed
• 1 small onion, diced
• 2 cloves garlic, minced
• 1 teaspoon cumin
• 1/2 teaspoon chili powder
• Salt and pepper to taste
• 1/2 cup shredded cheddar cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Roast sweet potatoes with olive oil, salt, and pepper until tender.
• Sauté onions and garlic until fragrant, then add chicken, black beans, cumin, chili powder, salt, and pepper.
• Layer chicken mixture and roasted sweet potatoes in a greased baking dish.
• Top with shredded cheddar cheese and bake 20–25 minutes until cheese is melted and bubbly.

This sweet potato, chicken, and black bean casserole is hearty, savory, and comforting.

It’s perfect for fall dinners or casual weeknight meals.

The combination of tender chicken, sweet potatoes, and beans creates a flavorful autumn dish.

Autumn Beef and Wild Rice Casserole

This autumn beef and wild rice casserole is rich, savory, and perfect for seasonal dinners.

Ground beef, wild rice, mushrooms, and root vegetables bake together with herbs and a creamy sauce.

The dish is filling, flavorful, and ideal for family dinners or cozy evenings.

A sprinkle of cheese on top adds a golden, bubbling finish.

Ingredients:

• 1 lb ground beef
• 1 cup wild rice, cooked
• 2 cups mushrooms, sliced
• 1 cup carrots, diced
• 1 onion, diced
• 2 cloves garlic, minced
• 1 cup beef broth
• 1/2 cup cream
• 1 teaspoon thyme
• Salt and pepper to taste
• 1/2 cup shredded cheddar cheese
• 2 tablespoons olive oil

Instructions:

• Preheat oven to 375°F (190°C).
• Sauté onions, garlic, mushrooms, and carrots in olive oil until tender.
• Add ground beef and cook until browned; season with thyme, salt, and pepper.
• Mix in cooked wild rice and cream until evenly combined.
• Transfer mixture to a greased baking dish and top with shredded cheddar.
• Bake 20–25 minutes until golden and bubbly.

This autumn beef and wild rice casserole is hearty, savory, and satisfying.

It’s perfect for fall family dinners or weekend meals.

The combination of beef, rice, and vegetables creates a comforting, flavorful dish.